SCHEMBL18516699

SCHEMBL18516699

Cc1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.73
KDR P35968 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307718 0.89 MET (0.73) METKDR
SCHEMBL308560 0.86 MET (0.73) METKDR
SCHEMBL18487300 0.85 MET (0.77) METKDR
SCHEMBL308075 0.85 MET (0.76) METKDR
SCHEMBL14230733 0.85 MET (0.70) METKDR
SCHEMBL307620 0.84 MET (1.00) METKDR
SCHEMBL13166667 0.84 MET (0.81) METKDR
SCHEMBL306290 0.83 MET (1.00) METKDR
SCHEMBL18516347 0.83 MET (0.69) METKDR
SCHEMBL896516 0.83 MET (0.62) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957498-B1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC (CA) 2017-02-15 EP disclosed