Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.52 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.52 |
| ▸ | AHCY | P23526 | 3/20 | 0.50 |
| ▸ | ADA | P00813 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 3/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439242 | 0.88 | POLB (0.67) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL16359945 | 0.88 | POLB (0.67) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL22393564 | 0.88 | POLB (0.52) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL10021397 | 0.88 | POLB (0.52) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL10021398 | 0.88 | POLB (0.67) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL23079356 | 0.88 | POLB (0.52) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL14064196 | 0.87 | AHCY (0.53) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL12378913 | 0.87 | AHCY (0.53) | POLBENPP1P2RY1AHCYADA | |
| Iodide SCHEMBL16244633 | 0.87 | POLB (0.66) | POLBENPP1P2RY1AHCYADA | |
| SCHEMBL16374436 | 0.86 | P2RY1 (0.66) | POLBENPP1P2RY1ADORA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027646-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | WO | disclosed |