Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264887 | 0.80 | RXFP1 (0.43) | MAPTLMNAALDH1A1GAAKMT2A | |
| SCHEMBL25252829 | 0.76 | CD274 (0.48) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL23146821 | 0.76 | ALK (0.48) | MAPTLMNA | |
| SCHEMBL27917866 | 0.76 | MAPT (0.53) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL22466151 | 0.76 | BAZ2B (0.50) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL23783089 | 0.76 | MAPT (0.58) | MAPTLMNACA12CA9POLB | |
| SCHEMBL29718646 | 0.76 | CA2 (0.42) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL19551857 | 0.76 | CA2 (0.42) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL23535770 | 0.73 | BCL2L1 (0.46) | LMNAKDM4E | |
| SCHEMBL17806585 | 0.72 | CREBBP (0.40) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024996-A1 | HYDROXY AMIDINE DERIVATIVE, PREPARATION METHOD AND USE IN MEDICINE THEREOF | 江苏恒瑞医药股份有限公司 | 2017-02-16 | — | — | WO | disclosed |