Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | LTK | P29376 | 4/20 | 0.36 |
| ▸ | CDK7 | P50613 | 4/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.36 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9413248 | 0.68 | RET (0.36) | RETLRRK2DAPK3MAP4K4KDR | |
| SCHEMBL9413252 | 0.67 | KDR (0.56) | RETLRRK2DAPK3MAP4K4KDR | |
| Vitamin B4 SCHEMBL4257555 | 0.67 | KDR (0.43) | RETLRRK2DAPK3MAP4K4KDR | |
| SCHEMBL14379846 | 0.61 | KDR (0.34) | RETLRRK2DAPK3MAP4K4KDR | |
| SCHEMBL12844194 | 0.60 | KDR (0.45) | RETLRRK2DAPK3MAP4K4KDR | |
| SCHEMBL16015971 | 0.60 | PI4KA (0.34) | RETLRRK2LIMK1PI4KAPI4K2B | |
| SCHEMBL16712838 | 0.60 | LRRK2 (0.37) | RETLRRK2DAPK3MAP4K4KDR | |
| SCHEMBL17379959 | 0.60 | PI4KA (0.31) | RETLRRK2PI4KAPI4K2BPI4K2A | |
| SCHEMBL1718947 | 0.59 | — | — | |
| SCHEMBL16364781 | 0.58 | DAPK3 (0.33) | RETLRRK2DAPK3MAP4K4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854799-B1 | CYCLIC DINUCLEOTIDE ANALOGUE, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2024-07-17 | — | — | EP | disclosed |
| EP-3854799-A1 | CYCLIC DINUCLEOTIDE ANALOGUE, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020117623-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2020117625-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2020057546-A1 | CYCLIC DINUCLEOTIDE ANALOGUE, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION | 上海迪诺医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |
| WO-2017027646-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | WO | disclosed |