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DAPK3

Death-associated protein kinase 3 · O43293 · DAPK3 on Sugi Atlas →

103,420 patent compounds predicted against DAPK3, 77,792 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL98881 SCHEMBL98881 0.57 3/20
SCHEMBL100736 SCHEMBL100736 0.50 3/20
SCHEMBL100040 SCHEMBL100040 0.48 3/20
SCHEMBL100903 SCHEMBL100903 0.47 3/20
SCHEMBL99210 SCHEMBL99210 0.43 3/20
SCHEMBL101240 SCHEMBL101240 0.41 3/20
Sunitinib Sunitinib (SCHEMBL8081) 1.00 2/20
Sunitinib Sunitinib (SCHEMBL8082) 1.00 2/20
Staurosporine Staurosporine (SCHEMBL8156) 1.00 2/20
Staurosporine Staurosporine (SCHEMBL8157) 1.00 2/20
Ruxolitinib Ruxolitinib (SCHEMBL99225) 1.00 2/20
Ruxolitinib Ruxolitinib (SCHEMBL101279) 1.00 2/20
SCHEMBL99245 SCHEMBL99245 0.98 2/20
SCHEMBL99371 SCHEMBL99371 0.98 2/20
SCHEMBL98692 SCHEMBL98692 0.92 2/20
Sunitinib Sunitinib (SCHEMBL18648) 0.92 2/20
Sunitinib Sunitinib (SCHEMBL55459) 0.84 2/20
Ruxolitinib Ruxolitinib (SCHEMBL99771) 0.84 2/20
Ruxolitinib Ruxolitinib (SCHEMBL100078) 0.84 2/20
SCHEMBL100845 SCHEMBL100845 0.80 2/20

Clinical trials — most relevant to DAPK3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer PHASE4UNKNOWN
Minocycline for the Treatment of Early-Phase Schizophrenia PHASE3COMPLETED
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity PHASE2RECRUITING
FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer PHASE1/PHASE2COMPLETED
Valuation of the Safety and Efficacy of Combination of Cryoablation and Dendric Cell/Cytokine-induced Killers Cells Treatment for Advanced Liver Cancers PHASE1/PHASE2UNKNOWN
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL PHASE1/PHASE2RECRUITING
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas PHASE1/PHASE2COMPLETED
Neoadjuvant Dabrafenib, Trametinib and/or Pembrolizumab in BRAF Mutant Resectable Stage III Melanoma PHASE2UNKNOWN
Pembrolizumab (MK-3475) in MM Patients With Residual Disease PHASE2COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Nilotinib in Huntington's Disease PHASE1UNKNOWN
Phase I Trial of LCL161 and Gemcitabine Plus Nab-Paclitaxel in Metastatic Pancreatic Cancer PHASE1UNKNOWN
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study PHASE1UNKNOWN
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 EARLY_PHASE1COMPLETED
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors nanACTIVE_NOT_RECRUITING
Impact of CASP3 Gene in Chemoresistance nanNOT_YET_RECRUITING
Apoptosis Markers in Aggressive Periodontitis nanCOMPLETED
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage nanCOMPLETED
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm nanCOMPLETED
Role of Vaspin in Pathophysiology of Pre-eclampsia nanUNKNOWN
Effect of Severe Trauma on PD1 and Its Legend (PD1/L1) on T Lymphocytes and Correlation With Mortality nanUNKNOWN
Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment nanUNKNOWN
Autophagy Bladder Cancer nanUNKNOWN
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA nanRECRUITING
Study on the Effect of PRKCB1 Modulating Inflammatory Factors and the Role for Developing Major Depressive Disorder nanUNKNOWN
Semen Analysis Changes in Covid-19 Positivepatients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DAPK3 binder may also engage these)

ProteinNameSimilarity
O88764 — 0.998 O88764 →
Q7SY49 — 0.991 Q7SY49 →
O54784 — 0.991 O54784 →
O08605 — 0.990 O08605 →
RPS6KB1 Ribosomal protein S6 kinase beta-1 0.990 landscape →
Q6TJY3 — 0.990 Q6TJY3 →
P07934 — 0.989 P07934 →
Q8BSK8 — 0.989 Q8BSK8 →
P08414 — 0.989 P08414 →
P00518 — 0.987 P00518 →
Q66I46 — 0.987 Q66I46 →
Q91VB2 — 0.987 Q91VB2 →
O08875 — 0.987 O08875 →
Q95266 — 0.987 Q95266 →
Q09137 — 0.987 Q09137 →
Q8N2I9 — 0.987 Q8N2I9 →
Q9ZUZ2 — 0.986 Q9ZUZ2 →
Q2LZZ7 — 0.986 Q2LZZ7 →
D3ZHP7 — 0.986 D3ZHP7 →
PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 0.986 landscape →
Q66JF3 — 0.986 Q66JF3 →
Q7T0B1 — 0.986 Q7T0B1 →
Q5EG47 — 0.986 Q5EG47 →
Q7TPS0 — 0.986 Q7TPS0 →
PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.986 landscape →
Q96QS6 — 0.986 Q96QS6 →
P08413 — 0.985 P08413 →
Q0V7M1 — 0.985 Q0V7M1 →
MYLK4 Myosin light chain kinase family member 4 0.985 landscape →
Q5RDH5 — 0.985 Q5RDH5 →