Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520702 | 0.85 | JAK1 (0.39) | PIK3CBGRM2CCNB2CDK1CDK4 | |
| SCHEMBL18520428 | 0.80 | TSHR (0.33) | PIK3CBJAK2JAK1TYK2JAK3 | |
| SCHEMBL18520610 | 0.79 | JAK2 (0.35) | PIK3CBJAK2JAK1TYK2JAK3 | |
| SCHEMBL18520430 | 0.79 | PDK4 (0.45) | JAK1CCNT1CDK9 | |
| SCHEMBL18520533 | 0.76 | HSP90AA1 (0.50) | GRM2JAK2JAK1TYK2JAK3 | |
| SCHEMBL18520608 | 0.75 | GRM2 (0.34) | GRM2 | |
| SCHEMBL18520431 | 0.75 | CDK9 (0.41) | GRM2CCNT1CDK9 | |
| SCHEMBL18520609 | 0.74 | DHODH (0.33) | GRM2 | |
| SCHEMBL18520517 | 0.72 | GRM2 (0.40) | GRM2POLB | |
| SCHEMBL18520551 | 0.72 | CDK9 (0.39) | GRM2KDM4ECCNT1CDK9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027768-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. (US) | 2017-02-16 | — | — | WO | disclosed |