Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 5/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524155 | 0.85 | PTGDR2 (0.41) | PTGDR2DRD2DPP4JAK2JAK1 | |
| SCHEMBL15057302 | 0.84 | PTGDR2 (0.42) | PTGDR2MAOBDRD2 | |
| SCHEMBL17061211 | 0.81 | PTGDR2 (0.41) | PTGDR2DRD2DPP4 | |
| SCHEMBL139334 | 0.73 | PTGDR2 (0.47) | PTGDR2MAOBDRD2 | |
| SCHEMBL24368273 | 0.72 | MAOB (0.50) | MAOB | |
| SCHEMBL29518276 | 0.72 | MAOB (0.50) | MAOB | |
| SCHEMBL7886073 | 0.72 | HTT (0.54) | DRD2 | |
| SCHEMBL17130188 | 0.71 | L3MBTL1 (0.47) | CDK9PTGDR2 | |
| SCHEMBL15056581 | 0.71 | PTGDR2 (0.49) | CDK9CCNT1PTGDR2 | |
| SCHEMBL138884 | 0.71 | PTGDR2 (0.49) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794563-B1 | HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2017-02-22 | — | — | EP | disclosed |