Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.59 |
| ▸ | JAK1 | P23458 | 20/20 | 0.59 |
| ▸ | JAK3 | P52333 | 19/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14751812 | 0.88 | JAK2 (0.75) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524748 | 0.86 | JAK2 (0.78) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524548 | 0.81 | JAK2 (0.79) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524479 | 0.80 | LMNA (0.38) | JAK2JAK1JAK3 | |
| SCHEMBL18524677 | 0.80 | JAK2 (0.79) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524737 | 0.79 | JAK2 (0.79) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524861 | 0.79 | JAK2 (0.67) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524665 | 0.78 | JAK2 (0.65) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524890 | 0.78 | JAK2 (0.66) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524458 | 0.78 | JAK2 (0.78) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |