Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 16/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524936 | 0.96 | SYK (0.46) | JAK2JAK1JAK3SYKKCNH2 | |
| SCHEMBL14738261 | 0.89 | SYK (0.58) | JAK2JAK1JAK3SYKKCNH2 | |
| Hydrochloric Acid SCHEMBL14737761 | 0.88 | SYK (0.57) | JAK2JAK1JAK3SYKKCNH2 | |
| SCHEMBL18524512 | 0.88 | JAK2 (0.57) | JAK2JAK1JAK3SYKCYP2C9 | |
| SCHEMBL18524930 | 0.87 | JAK2 (0.46) | JAK2JAK1JAK3SYKKCNH2 | |
| SCHEMBL18524863 | 0.85 | SYK (0.48) | JAK2JAK1JAK3SYKKCNH2 | |
| SCHEMBL14738164 | 0.84 | SYK (0.56) | JAK2JAK1JAK3SYKKCNH2 | |
| Hydrochloric Acid SCHEMBL14738575 | 0.84 | SYK (0.56) | JAK2JAK1JAK3SYKKCNH2 | |
| SCHEMBL18524886 | 0.81 | JAK2 (0.53) | JAK2JAK1JAK3SYKCYP2C9 | |
| SCHEMBL18524523 | 0.80 | SYK (0.49) | JAK2JAK1JAK3SYKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |