Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524599 | 0.96 | JAK2 (0.46) | SYKJAK2JAK1JAK3KCNH2 | |
| SCHEMBL14738164 | 0.89 | SYK (0.56) | SYKJAK2JAK1JAK3KCNH2 | |
| Hydrochloric Acid SCHEMBL14738575 | 0.88 | SYK (0.56) | SYKJAK2JAK1JAK3KCNH2 | |
| SCHEMBL18524863 | 0.87 | SYK (0.48) | SYKJAK2JAK1JAK3KCNH2 | |
| SCHEMBL18524512 | 0.86 | JAK2 (0.57) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL18524930 | 0.86 | JAK2 (0.46) | SYKJAK2JAK1JAK3KCNH2 | |
| SCHEMBL14738261 | 0.84 | SYK (0.58) | SYKJAK2JAK1JAK3KCNH2 | |
| Hydrochloric Acid SCHEMBL14737761 | 0.84 | SYK (0.57) | SYKJAK2JAK1JAK3KCNH2 | |
| SCHEMBL18524470 | 0.83 | SYK (0.52) | SYKJAK2JAK1JAK3KCNH2 | |
| SCHEMBL18524533 | 0.81 | SYK (0.70) | SYKJAK2JAK1JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |