Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pentachlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentachlorophenol SCHEMBL10336353 | 0.87 | TSHR (0.67) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Perchlorobenzene SCHEMBL28725149 | 0.86 | TSHR (0.55) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL7922521 | 0.84 | TSHR (0.62) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL6840640 | 0.83 | TSHR (0.71) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL28030118 | 0.82 | HSD17B10 (0.83) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL23121452 | 0.82 | HSD17B10 (1.00) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL1492 | 0.82 | HSD17B10 (1.00) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL1330735 | 0.82 | HSD17B10 (1.00) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Perchlorobenzene SCHEMBL28269084 | 0.82 | HSD17B10 (1.00) | TSHRHPGDHSD17B10ALDH1A1MEN1 | |
| Pentachlorophenol SCHEMBL5315995 | 0.82 | HSD17B10 (1.00) | TSHRHPGDHSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115282078-B | Full-effect eye cream and preparation method thereof | 广东丸美生物技术股份有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-108704384-B | Water purification filter rod | 江西怡润科技有限公司 | 2021-04-16 | — | — | CN | claimed |
| CN-108641235-B | Antibacterial PVC plastic and preparation method thereof | 福建宏翔塑胶有限公司 | 2020-05-05 | — | — | CN | claimed |
| CN-109824480-A | The process of ethyl alcohol in a kind of separating-purifying coal oil rectification residue | 北控城市(北京)环境科技有限公司 | 2019-05-31 | — | — | CN | claimed |
| CN-108641235-A | Antibacterial pvc plastic and preparation method thereof | 占夏青 | 2018-10-12 | — | — | CN | claimed |
| CN-102869446-B | High-specific surface area fiber nano SiO 2 particle | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2016-03-30 | — | — | CN | claimed |
| CN-102869446-A | High surface area fibrous silica nanoparticles | UNIV KING ABDULLAH SCI & TECH | 2013-01-09 | — | — | CN | claimed |
| CN-102292420-A | Preparation of polyol ester lubricants for refrigeration systems | — | 2011-12-21 | — | — | CN | claimed |
| CN-1004695-B | Recovery of glycerol from salt-containing wastewater | 国际壳牌研究有限公司 | 1989-07-05 | — | — | CN | claimed |
| CN-85109000-A | From brine waste, reclaim glycerine | — | 1986-07-09 | — | — | CN | claimed |
| CN-118222414-A | Filamentous fungi producing multiple polyols and application of filamentous fungi in Daqu | 山西杏花村汾酒厂股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118085256-A | Five-center Schiff base metal catalyst and preparation method thereof and preparation method of polyglycolic acid | 中国科学院长春应用化学研究所 | 2024-05-28 | — | — | CN | disclosed |
| CN-118048789-A | Hydrophilic cool fabric and manufacturing method thereof | 财团法人纺织产业综合研究所 | 2024-05-17 | — | — | CN | disclosed |
| CN-117567935-A | Hardening coating composition, preparation method, hardening film and display device | 深圳市华星光电半导体显示技术有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-114976010-B | Negative electrode additive and preparation method and application thereof | 深圳市研一新材料有限责任公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-1139946-A | Use of bicontinuous microemulsions as pressure sensitive adhesives | MINNESOTA MINING & MFG (US) | 1997-01-08 | — | — | CN | disclosed |
| CN-1091148-A | The refrigeration working fluid compositions that contains C2H4F2 C2H4F2 or pentafluoride ethane | EXXON CHEMICAL PATENTS INC (US) | 1994-08-24 | — | — | CN | disclosed |
| CN-1089294-A | The refrigeration working fluid compositions that contains Halothane | EXXON CHEMICAL PATENTS INC (US) | 1994-07-13 | — | — | CN | disclosed |
| CN-1004695-B | Recovery of glycerol from salt-containing wastewater | 国际壳牌研究有限公司 | 1989-07-05 | — | — | CN | disclosed |
| CN-85109000-A | From brine waste, reclaim glycerine | — | 1986-07-09 | — | — | CN | disclosed |