Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 11/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 2/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22959959 | 0.85 | ERN1 (0.43) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL4587473 | 0.79 | ERN1 (0.47) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL29935588 | 0.79 | ERN1 (0.47) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL14128913 | 0.78 | PDGFRB (0.38) | ERN1KDM4EMEN1KMT2A | |
| SCHEMBL24250212 | 0.78 | IRAK4 (0.44) | ERN1TYR | |
| SCHEMBL29955516 | 0.75 | KDM4E (0.47) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL29953180 | 0.74 | MEN1 (0.50) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL9807462 | 0.74 | MEN1 (0.50) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL12444115 | 0.72 | TLR8 (0.47) | KDM4ENPSR1CCR1CCR5CCR8 | |
| SCHEMBL8764571 | 0.71 | CCR1 (0.53) | ERN1KDM4EMEN1NPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025849-A1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS | PFIZER INC. (US) | 2017-02-16 | — | — | WO | disclosed |