Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859162 | 0.93 | ABCB1 (0.44) | ABCB1ROCK1ROCK2RAB9ANR3C2 | |
| SCHEMBL1856714 | 0.90 | ABCB1 (0.44) | ABCB1ROCK1ROCK2RAB9ANR3C2 | |
| SCHEMBL62554 | 0.90 | ABCB1 (0.47) | ABCB1ROCK1ROCK2RAB9ANR3C2 | |
| SCHEMBL63192 | 0.86 | ABCB1 (0.43) | ABCB1ROCK1ROCK2NPC1RAB9A | |
| SCHEMBL64112 | 0.86 | ABCB1 (0.44) | ABCB1ROCK1ROCK2RAB9ANR3C2 | |
| SCHEMBL65150 | 0.86 | ABCB1 (0.49) | ABCB1ROCK1ROCK2NPC1RAB9A | |
| SCHEMBL1853874 | 0.85 | ABCB1 (0.45) | ABCB1ROCK1ROCK2NPC1RAB9A | |
| SCHEMBL65051 | 0.84 | HDAC1 (0.44) | ABCB1ROCK1ROCK2NPC1RAB9A | |
| SCHEMBL62361 | 0.84 | ABCB1 (0.47) | ABCB1ROCK1ROCK2RAB9ANR3C2 | |
| SCHEMBL64118 | 0.84 | KCNQ3 (0.52) | ABCB1ROCK1ROCK2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-B1 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2011-05-25 | — | — | EP | claimed |