SCHEMBL1852990

SCHEMBL1852990

CCCCCCCCOc1ccc(C[N+](CC)Cc2ccccc2C(F)(F)F)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.43
MAOA P21397 1/20 0.42
LTA4H P09960 2/20 0.42
NR5A1 Q13285 1/20 0.40
MMP2 P08253 1/20 0.39
MMP3 P08254 1/20 0.39
MMP9 P14780 1/20 0.39
PDK2 Q15119 1/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TP53 P04637 1/20 0.38
HPGD P15428 1/20 0.38
PLG P00747 1/20 0.37
PRSS1 P07477 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1855383 0.81 FFAR1 (0.42) MAOBMAOAMMP2NPC1RAB9A
SCHEMBL6023242 0.80 MAOB (0.46) MAOBMAOALTA4HNR5A1PDK2
SCHEMBL1853979 0.79 KDM4E (0.49) MAOBLTA4HCYP1A2CYP3A4CYP2C9
SCHEMBL1856177 0.73 SLC2A1 (0.40) THRATHRBCYP2C9
SCHEMBL5133737 0.73 TP53 (0.43) MAOBMAOATHRATHRBCYP1A2
SCHEMBL1857139 0.72 MEN1 (0.44) MAOBMAOANPC1THRATHRB
SCHEMBL5049002 0.71 LTA4H (0.43) MAOBLTA4HNR5A1PDK2NPC1
SCHEMBL27666007 0.69 IDO1 (0.53) MAOBMAOA
SCHEMBL29919692 0.68 S1PR1 (0.50) THRATHRBCYP1A2CYP3A4CYP2C9
SCHEMBL10778567 0.68 S1PR1 (0.50) THRATHRBCYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1470102-B1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) MERCK SERONO SA (CH) 2011-05-25 EP disclosed