Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ME2 | P23368 | 2/20 | 0.43 |
| ▸ | ME1 | P48163 | 2/20 | 0.43 |
| ▸ | ME3 | Q16798 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21457821 | 0.83 | NAMPT (0.53) | SIGMAR1NAMPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18530398 | 0.81 | MAPT (0.41) | SIGMAR1SMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL18530448 | 0.81 | MAPT (0.41) | SIGMAR1SMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL23291239 | 0.79 | NAMPT (0.55) | SIGMAR1NAMPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3836217 | 0.79 | NAMPT (0.54) | SIGMAR1NAMPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3706363 | 0.77 | NAMPT (0.52) | SIGMAR1NAMPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL19211125 | 0.77 | SIGMAR1 (0.52) | SIGMAR1NAMPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22957300 | 0.76 | NAMPT (0.51) | NAMPTCA1CA2 | |
| SCHEMBL19211083 | 0.74 | SMN1; SMN2 (0.52) | SIGMAR1NAMPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18591875 | 0.74 | MAPT (0.49) | SMN1; SMN2MEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337476-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017030814-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2017-02-23 | — | — | WO | disclosed |