Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.40 |
| ▸ | MTTP | P55157 | 6/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.38 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721473 | 0.80 | ALOX5 (0.42) | MTTPALOX5GGPS1VKORC1 | |
| SCHEMBL1852378 | 0.77 | ALOX5 (0.42) | MTTPALOX5GGPS1C3AR1VKORC1 | |
| SCHEMBL4324770 | 0.76 | ALOX5 (0.46) | MTTPALOX5GGPS1VKORC1 | |
| SCHEMBL4313217 | 0.76 | MTTP (0.38) | MTTPALOX5GGPS1CNR2VKORC1 | |
| SCHEMBL1239482 | 0.75 | SERPINE1 (0.47) | ALOX5GGPS1VKORC1 | |
| SCHEMBL6918012 | 0.75 | ALOX5 (0.47) | ALOX5GGPS1VKORC1 | |
| SCHEMBL5046221 | 0.75 | ALOX5 (0.47) | ALOX5GGPS1VKORC1 | |
| SCHEMBL6718959 | 0.73 | SOAT1 (0.52) | CNR2 | |
| SCHEMBL1854365 | 0.73 | ALOX5 (0.37) | MTTPALOX5GGPS1 | |
| SCHEMBL1856644 | 0.73 | EPHX2 (0.48) | ALOX5GGPS1CNR2VKORC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |