Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 16/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731505 | 0.85 | KCNJ1 (0.53) | KCNJ1 | |
| SCHEMBL17268268 | 0.84 | PPARD (0.43) | KCNJ1 | |
| SCHEMBL15832633 | 0.79 | KCNJ1 (0.47) | KCNJ1ALDH1A1HPGD | |
| SCHEMBL4549512 | 0.78 | KCNJ1 (0.58) | KCNJ1 | |
| SCHEMBL15825922 | 0.77 | TP53 (0.49) | KCNJ1TP53 | |
| Hydrochloric Acid SCHEMBL15192604 | 0.77 | KCNJ1 (0.57) | KCNJ1 | |
| SCHEMBL15825095 | 0.73 | NOTUM (0.43) | KCNJ1ALDH1A1HPGD | |
| SCHEMBL19597281 | 0.71 | KCNJ1 (0.72) | KCNJ1 | |
| SCHEMBL19002833 | 0.70 | MTNR1A (0.47) | — | |
| Lithium Ion SCHEMBL15878970 | 0.68 | KCNJ1 (0.40) | KCNJ1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9573961-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2017-02-21 | — | — | US | disclosed |