Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20476685 | 0.89 | IKBKB (0.46) | ALDH1A1HPGDSMN1; SMN2MAP4K1HSP90AA1 | |
| SCHEMBL21565914 | 0.86 | ALDH1A1 (0.41) | ALDH1A1HPGDSMN1; SMN2MAP4K1HSP90AA1 | |
| SCHEMBL6865515 | 0.84 | MAPT (0.48) | ALDH1A1HPGDSMN1; SMN2HSP90AA1PDK2 | |
| SCHEMBL21544269 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2HSP90AA1PDK2 | |
| SCHEMBL1708822 | 0.82 | KMT2A (0.57) | ALDH1A1HPGDSMN1; SMN2MAP4K1ABL1 | |
| SCHEMBL29447970 | 0.81 | PDK2 (0.47) | ALDH1A1HPGDSMN1; SMN2HSP90AA1PDK2 | |
| SCHEMBL384544 | 0.81 | MAPT (0.46) | ALDH1A1HPGDSMN1; SMN2HSP90AA1PDK2 | |
| SCHEMBL13205433 | 0.81 | PDK2 (0.47) | ALDH1A1HPGDSMN1; SMN2HSP90AA1PDK2 | |
| SCHEMBL5065113 | 0.81 | PDK2 (0.47) | ALDH1A1MAP4K1HSP90AA1PDK2ABL1 | |
| SCHEMBL3806699 | 0.81 | MAPT (0.51) | ALDH1A1SMN1; SMN2MAP4K1ABL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242116-B2 | Fused thiazole derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2012-08-14 | — | — | US | disclosed |
| EP-2035436-B1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2011-05-25 | — | — | EP | disclosed |
| US-20100137302-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137302-A1 | Fused Thiazole Derivatives as Kinase Inhibitors | PI4KA, PDPK1, PIK3CA | ALDH1A1 2279/4885HPGD 2416/4885SMN1; SMN2 1521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.