Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 3/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12176191 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL18790105 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL12074050 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL12176383 | 0.95 | ALDH1A1 (0.44) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL18609471 | 0.94 | HSD17B10 (0.41) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL18790219 | 0.94 | HSD17B10 (0.41) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL12176122 | 0.94 | ALDH1A1 (0.41) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL12176080 | 0.94 | HSD17B10 (0.41) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL14959034 | 0.94 | EPHX2 (0.41) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M | |
| SCHEMBL18790108 | 0.94 | EPHX2 (0.41) | ALDH1A1CYP1A2CYP2C9RXFP1UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4015504-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| EP-3508477-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2021-11-10 | — | — | EP | disclosed |
| EP-3508477-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |
| US-9573897-B2 | C5AR antagonists | CHEMOCENTRYX, INC. (US) | 2017-02-21 | — | — | US | disclosed |