Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077437 | 0.84 | MEN1 (0.46) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL13077173 | 0.82 | MEN1 (0.43) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL13077172 | 0.81 | NPC1 (0.50) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL9061218 | 0.80 | POLB (0.58) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL30484011 | 0.80 | POLB (0.58) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL26360832 | 0.80 | MEN1 (0.47) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL9807017 | 0.79 | NPC1 (0.51) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL13077755 | 0.78 | NPC1 (0.47) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL20804911 | 0.76 | DPP4 (0.47) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL13077117 | 0.76 | DPP4 (0.47) | NPC1RAB9AHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231194-B1 | FOLATE-IRNA CONJUGATES | ALNYLAM PHARMACEUTICALS INC (US) | 2017-02-22 | — | — | EP | disclosed |