Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 11/20 | 0.42 |
| ▸ | JAK1 | P23458 | 11/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534795 | 1.00 | JAK3 (0.46) | JAK3SYKJAK2JAK1HPGD | |
| SCHEMBL18534999 | 1.00 | JAK3 (0.46) | JAK3SYKJAK2JAK1HPGD | |
| SCHEMBL18535074 | 0.93 | SYK (0.45) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534498 | 0.92 | SYK (0.42) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534487 | 0.91 | JAK3 (0.51) | JAK3SYKJAK2JAK1 | |
| SCHEMBL18534614 | 0.91 | SYK (0.55) | JAK3SYKJAK2JAK1 | |
| SCHEMBL18534634 | 0.91 | SYK (0.55) | JAK3SYKJAK2JAK1 | |
| SCHEMBL18534561 | 0.90 | SYK (0.52) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534736 | 0.90 | TAS1R3 (0.42) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534995 | 0.90 | TAS1R3 (0.42) | JAK3SYKJAK2JAK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |