Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.72 |
| ▸ | JAK1 | P23458 | 20/20 | 0.72 |
| ▸ | JAK3 | P52333 | 19/20 | 0.72 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534473 | 0.84 | JAK2 (0.47) | JAK2JAK1JAK3 | |
| SCHEMBL14751767 | 0.83 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL14752111 | 0.83 | JAK2 (0.65) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534451 | 0.83 | JAK2 (0.51) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534901 | 0.76 | JAK1 (0.42) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18524748 | 0.76 | JAK2 (0.78) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534535 | 0.76 | JAK2 (0.64) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL14751097 | 0.74 | JAK2 (0.54) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534692 | 0.74 | JAK2 (0.53) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL14751126 | 0.74 | JAK2 (0.82) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |