Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.51 |
| ▸ | JAK1 | P23458 | 20/20 | 0.51 |
| ▸ | JAK3 | P52333 | 20/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534535 | 0.83 | JAK2 (0.64) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534692 | 0.83 | JAK2 (0.53) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534870 | 0.83 | JAK2 (0.72) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534630 | 0.72 | IRAK4 (0.35) | — | |
| SCHEMBL14752120 | 0.70 | JAK2 (0.45) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL2378696 | 0.70 | JAK2 (0.45) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534553 | 0.69 | JAK2 (0.36) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18534427 | 0.69 | JAK3 (0.34) | JAK2JAK1JAK3 | |
| SCHEMBL18534669 | 0.68 | JAK2 (0.43) | JAK2JAK1JAK3 | |
| SCHEMBL2379596 | 0.68 | JAK1 (1.00) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |