Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 17/20 | 0.97 |
| ▸ | KLKB1 | P03952 | 14/20 | 0.97 |
| ▸ | F9 | P00740 | 8/20 | 0.97 |
| ▸ | F12 | P00748 | 1/20 | 0.79 |
| ▸ | PLAT | P00750 | 1/20 | 0.79 |
| ▸ | PROC | P04070 | 1/20 | 0.79 |
| ▸ | F7 | P08709 | 1/20 | 0.79 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.79 |
| ▸ | CTRL | P40313 | 1/20 | 0.79 |
| ▸ | CTRB2 | Q6GPI1 | 1/20 | 0.79 |
| ▸ | CTRC | Q99895 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15594179 | 0.99 | F11 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL18523864 | 0.93 | KLKB1 (0.89) | F11KLKB1F9F12PLAT | |
| SCHEMBL17991856 | 0.90 | KLKB1 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL16782297 | 0.88 | F11 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL15597198 | 0.88 | F11 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL15456517 | 0.88 | F11 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL15456413 | 0.88 | F11 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL15597251 | 0.88 | F11 (1.00) | F11KLKB1F9F12PLAT | |
| SCHEMBL15594207 | 0.86 | KLKB1 (0.77) | F11KLKB1F9 | |
| SCHEMBL18536070 | 0.85 | F11 (0.98) | F11KLKB1F9F12PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951071-B2 | Dihydropyridone P1 as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-24 | — | — | US | disclosed |
| EP-2880026-B1 | DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-02-22 | — | — | EP | disclosed |