Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18536615 | 0.90 | MTOR (0.52) | MTORKCNH2CACNA1GCACNA1BEPHX2 | |
| SCHEMBL2068031 | 0.90 | MTOR (0.52) | MTORKCNH2CACNA1GCACNA1BEPHX2 | |
| Hydrochloric Acid SCHEMBL2067983 | 0.89 | MTOR (0.52) | MTORKCNH2CACNA1GCACNA1BEPHX2 | |
| SCHEMBL9970048 | 0.80 | EPHX2 (0.51) | KCNH2EPHX2MCHR1 | |
| Hydrochloric Acid SCHEMBL2069161 | 0.80 | EPHX2 (0.50) | KCNH2EPHX2MCHR1 | |
| SCHEMBL2068332 | 0.79 | NPC1 (0.47) | SMN1; SMN2POLBMAPTKMT2AEPHX2 | |
| SCHEMBL18536579 | 0.79 | NPC1 (0.47) | SMN1; SMN2POLBMAPTKMT2AEPHX2 | |
| SCHEMBL13962125 | 0.79 | EPHX2 (0.49) | MTORSMN1; SMN2POLBMAPTEPHX2 | |
| SCHEMBL18536590 | 0.79 | EPHX2 (0.49) | MTORSMN1; SMN2POLBMAPTEPHX2 | |
| SCHEMBL2067558 | 0.79 | EPHX2 (0.49) | MTORSMN1; SMN2POLBMAPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170860-B9 | BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2017-02-22 | — | — | EP | disclosed |