Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119216 | 0.88 | ALDH1A1 (0.50) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL1853485 | 0.85 | TSHR (0.46) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL4277750 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL1853887 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL1853482 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL4119222 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL4119214 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL1849605 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL4272956 | 0.79 | KMT2A (0.48) | ALDH1A1KDM4ETSHRHTTKMT2A | |
| SCHEMBL1851581 | 0.78 | NPC1 (0.51) | ALDH1A1KDM4ETSHRHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |