Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD5 | P21918 | 1/20 | 0.57 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.57 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.57 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | ATR | Q13535 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18538912 | 0.93 | DRD5 (0.48) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18541300 | 0.91 | DRD5 (0.58) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18541358 | 0.90 | DRD5 (0.47) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538925 | 0.90 | DRD5 (0.57) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538910 | 0.86 | DRD5 (0.68) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL21444465 | 0.86 | DRD5 (0.50) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18541364 | 0.84 | DRD5 (0.67) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538923 | 0.83 | DRD5 (0.68) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538922 | 0.82 | DRD5 (0.69) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18541299 | 0.82 | DRD5 (0.48) | DRD5SCNN1ASCNN1BSCNN1GHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337483-B1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2019-10-09 | — | — | EP | disclosed |
| US-20180186774-A1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2018-07-05 | — | — | US | disclosed |
| US-9938256-B2 | Annelated benzamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-04-10 | — | — | US | disclosed |
| WO-2017028926-A1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | WO | disclosed |
| US-20170050952-A1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050952-A1 | NOVEL ANNELATED BENZAMIDES | HDAC10, HDAC11, H1-0 | DRD5 608/4885SCNN1A 667/4885SCNN1B 1056/4885 |
| US-20180186774-A1 | NOVEL ANNELATED BENZAMIDES | HDAC10, HDAC11, H1-0 | DRD5 608/4885SCNN1A 667/4885SCNN1B 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.