Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 9/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540590 | 0.85 | BRD4 (0.34) | BRD4P2RX7SMN1; SMN2 | |
| SCHEMBL18540499 | 0.83 | PRMT5 (0.35) | CYP1A2CYP2C9CYP2C19MAPTPLA2G1B | |
| SCHEMBL18540484 | 0.82 | AR (0.35) | CYP1A2CYP2C9CYP2C19MAPTPLA2G1B | |
| SCHEMBL18540498 | 0.81 | CHEK1 (0.39) | CYP1A2CYP2C9CYP2C19MAPTPLA2G1B | |
| SCHEMBL17213096 | 0.80 | GRK6 (0.36) | ALDH1A1KMT2ABRD4GRK6HPGD | |
| SCHEMBL18540474 | 0.80 | MAPT (0.38) | CYP1A2CYP2C9CYP2C19MAPTPLA2G1B | |
| SCHEMBL18540504 | 0.79 | GRK6 (0.51) | MAPTALDH1A1KMT2ALMNAGRK6 | |
| SCHEMBL18540469 | 0.79 | PRKAG1 (0.36) | CYP1A2CYP2C9CYP2C19MAPTPLA2G1B | |
| SCHEMBL18540471 | 0.78 | SMN1; SMN2 (0.48) | MAPTALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL18540482 | 0.78 | MEN1 (0.40) | CYP1A2CYP2C9CYP2C19MAPTPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | GRK6, GRK2, GRK3 | CYP1A2 4876/4885CYP2C9 4877/4885CYP2C19 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.