Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | USP2 | O75604 | 7/20 | 0.65 |
| ▸ | SLC29A2 | Q14542 | 2/20 | 0.65 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | CYBB | P04839 | 5/20 | 0.57 |
| ▸ | NOX4 | Q9NPH5 | 5/20 | 0.57 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.57 |
| ▸ | NOX3 | Q9HBY0 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18542996 | 0.90 | MAPT (0.80) | MAPTUSP2SLC29A2SLC29A1POLB | |
| SCHEMBL18542998 | 0.81 | MAPT (0.76) | MAPTUSP2SLC29A2SLC29A1POLB | |
| SCHEMBL21530475 | 0.74 | MAPT (0.85) | MAPTUSP2SLC29A2SLC29A1POLB | |
| SCHEMBL4544846 | 0.73 | MAPT (0.59) | MAPTPOLBALDH1A1GAAMAPK1 | |
| SCHEMBL824521 | 0.73 | MAPT (0.59) | MAPTPOLBALDH1A1GAAMAPK1 | |
| SCHEMBL14184730 | 0.73 | APP (0.48) | MAPTPOLBALDH1A1GAAMEN1 | |
| SCHEMBL15662479 | 0.72 | CYBB (1.00) | MAPTUSP2SLC29A2SLC29A1POLB | |
| SCHEMBL4544867 | 0.71 | MAPT (0.56) | MAPTPOLBALDH1A1GAAMAPK1 | |
| SCHEMBL15660042 | 0.71 | CYBB (1.00) | MAPTUSP2SLC29A2SLC29A1POLB | |
| SCHEMBL17999847 | 0.71 | CYBB (1.00) | MAPTUSP2SLC29A2SLC29A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017031116-A1 | SMALL MOLECULE INHIBITORS OF KU70/80 AND USES THEREOF | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-02-23 | — | — | WO | disclosed |