Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4113977 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1854355 | 0.78 | KMT2A (0.43) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL4113981 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1853482 | 0.70 | ALDH1A1 (0.46) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1851522 | 0.69 | MAPT (0.57) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1849131 | 0.69 | KDM4E (0.54) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1848269 | 0.69 | CSNK2B (0.49) | — | |
| SCHEMBL1852416 | 0.69 | HPGD (0.58) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1852418 | 0.69 | HPGD (0.53) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL1852593 | 0.68 | KMT2A (0.53) | ALDH1A1HPGDKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |