SCHEMBL18544259

SCHEMBL18544259

COc1ccc2c(OC)ccc(I)c2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
ALDH1A1 P00352 4/20 0.46
MAPT P10636 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
CYP3A4 P08684 1/20 0.46
THRB P10828 1/20 0.46
NQO1 P15559 1/20 0.44
KDM4E B2RXH2 1/20 0.42
TSHR P16473 1/20 0.42
GFER P55789 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CYP1A2 P05177 3/20 0.41
CYP1A1 P04798 2/20 0.41
CYP1B1 Q16678 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29792960 0.79 ALDH1A1 (0.41) CA12CA1CA2CA7CA9
SCHEMBL19595037 0.78 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL30776243 0.77 CA12 (0.62) CA12CA1CA2CA7CA9
SCHEMBL29445512 0.77 CA12 (0.62) CA12CA1CA2CA7CA9
SCHEMBL388185 0.77 CA12 (0.62) CA12CA1CA2CA7CA9
SCHEMBL481218 0.77 CA12 (0.62) CA12CA1CA2CA7CA9
SCHEMBL1402343 0.77 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL1402585 0.77 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL1402590 0.77 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL15266286 0.77 CA12 (0.52) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017029602-A2 COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-02-23 WO disclosed