Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 14/20 | 0.77 |
| ▸ | CA2 | P00918 | 1/20 | 0.73 |
| ▸ | NCF1 | P14598 | 1/20 | 0.73 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203051 | 1.00 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12203050 | 1.00 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL14144697 | 0.94 | CHKA (0.69) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12228678 | 0.92 | CHKA (0.67) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12203052 | 0.92 | CHKA (0.67) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL1172508 | 0.92 | MC4R (0.74) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12018137 | 0.92 | MC4R (0.74) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12203047 | 0.88 | CXCR4 (0.63) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL14612427 | 0.88 | CHKA (0.75) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12018071 | 0.88 | MC4R (0.79) | CHKACA2NCF1PRMT6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337519-B1 | COMPOSITIONS COMPRISING MACROCYCLE DERIVATIVES INCORPORATING BRIDGED MACROCYCLES AND METHODS OF PRODUCING AND USING SAME | SOUTHWESTERN OKLAHOMA STATE UNIV (US) | 2021-12-01 | — | — | EP | disclosed |
| US-20210179606-A1 | COMPOSITIONS COMPRISING MACROCYCLE DERIVATIVES INCORPORATING BRIDGED MACROCYCLES AND METHODS OF PRODUCING AND USING SAME | SOUTHWESTERN OKLAHOMA STATE UNIV (US) | 2021-06-17 | — | — | US | disclosed |
| US-10927108-B2 | Compositions comprising macrocycle derivatives incorporating bridged macrocycles and methods of producing and using same | SOUTHWESTERN OKLAHOMA STATE UNIVERSITY (US) | 2021-02-23 | — | — | US | disclosed |
| WO-2017030728-A1 | COMPOSITIONS COMPRISING MACROCYCLE DERIVATIVES INCORPORATING BRIDGED MACROCYCLES AND METHODS OF PRODUCING AND USING SAME | SOUTHWESTERN OKLAHOMA STATE UNIVERSITY (US) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927108-B2 | Compositions comprising macrocycle derivatives incorporating bridged macrocycles and methods of producing and using same | HCCS, CYCS, CYC1 | CHKA 302/4885CA2 3930/4885NCF1 2948/4885 |
| US-20210179606-A1 | COMPOSITIONS COMPRISING MACROCYCLE DERIVATIVES INCORPORATING BRIDGED MACROCYCLES AND METHODS OF PRODUCING AND USING SAME | HCCS, CYCS, CYC1 | CHKA 302/4885CA2 3930/4885NCF1 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.