CYCS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3704146	1.00	6/20
SCHEMBL4388693	1.00	6/20
SCHEMBL3701840	0.93	6/20
SCHEMBL3707006	0.93	6/20
SCHEMBL3696314	0.91	6/20
SCHEMBL3697511	0.91	6/20
SCHEMBL4401180	0.91	6/20
SCHEMBL4395653	0.90	6/20
SCHEMBL3698065	0.90	6/20
SCHEMBL4397286	0.90	6/20
SCHEMBL3703653	0.89	6/20
SCHEMBL4398368	0.87	6/20
SCHEMBL3699042	0.87	6/20
SCHEMBL4541497	0.86	6/20
SCHEMBL5955166	0.86	6/20
SCHEMBL4391634	0.86	6/20
SCHEMBL3708139	0.85	6/20
SCHEMBL5955406	0.84	6/20
SCHEMBL3702577	0.84	6/20
SCHEMBL4396565	0.83	6/20

Clinical trials — most relevant to CYCS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R	PHASE4	WITHDRAWN
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Prognostic Value of Plasma Mitochondrial DNA and Cytochrome C After Cardiac Arrest	nan	UNKNOWN
Leg Ulcers Standards of Care Enhancement	nan	COMPLETED
Effects of Chronic Dietary Exposure to Branched Chain Amino Acids	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Genetic Diagnosis in Inborn Errors of Metabolism	nan	ENROLLING_BY_INVITATION
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
In and ex Vivo Mitochondrial Function of the Heart	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Choroid Plexus Dysfunction in Neurological Diseases	nan	RECRUITING
LIPCAR, Cuproptosis, and Α-SMA in the Pathogenesis of AMI and Remodeling	nan	NOT_YET_RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST)	nan	UNKNOWN
Mitochondrial Function in Septic Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CYCS binder may also engage these)

Protein	Name	Similarity
Q5RFH4	—	1.000	Q5RFH4 →
Q6WUX8	—	1.000	Q6WUX8 →
P99998	—	1.000	P99998 →
P00002	—	1.000	P00002 →
Q52V08	—	1.000	Q52V08 →
P81280	—	1.000	P81280 →
P00014	—	1.000	P00014 →
Q7YR71	—	1.000	Q7YR71 →
P62898	—	1.000	P62898 →
P00015	—	1.000	P00015 →
P00003	—	1.000	P00003 →
Q640U4	—	1.000	Q640U4 →
Q52V10	—	1.000	Q52V10 →
P67882	—	1.000	P67882 →
P68099	—	1.000	P68099 →
P68100	—	1.000	P68100 →
Q6GQE4	—	1.000	Q6GQE4 →
P67881	—	1.000	P67881 →
P21665	—	1.000	P21665 →
P68098	—	1.000	P68098 →
P00012	—	0.999	P00012 →
P00011	—	0.999	P00011 →
P68517	—	0.998	P68517 →
B4USV4	—	0.998	B4USV4 →
P00008	—	0.998	P00008 →
P68519	—	0.998	P68519 →
P68518	—	0.998	P68518 →
P00013	—	0.998	P00013 →
P10715	—	0.998	P10715 →
Q6NTN0	—	0.997	Q6NTN0 →