Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 8/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238900 | 0.85 | BACE1 (0.43) | PDE2AOPRM1KEAP1NFE2L2LMNA | |
| SCHEMBL186787 | 0.81 | HPGDS (0.43) | OPRM1ADAMTS4OPRK1 | |
| SCHEMBL2384740 | 0.79 | CNR2 (0.41) | PDE2AOPRM1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL21774502 | 0.77 | HTT (0.50) | LMNASMN1; SMN2ALDH1A1PHGDHHTT | |
| SCHEMBL2328745 | 0.77 | HTT (0.50) | LMNASMN1; SMN2ALDH1A1PHGDHHTT | |
| SCHEMBL2238200 | 0.77 | HTT (0.50) | LMNASMN1; SMN2ALDH1A1PHGDHHTT | |
| SCHEMBL1935307 | 0.77 | PPARG (0.42) | PPARGPPARAEPHX2ADAMTS4LMNA | |
| SCHEMBL2240306 | 0.75 | PRSS1 (0.44) | PPARGPPARAEPHX2ADAMTS4SMN1; SMN2 | |
| SCHEMBL16989064 | 0.73 | RECQL (0.38) | PPARGPPARAPDE2ALMNASMN1; SMN2 | |
| SCHEMBL3976209 | 0.72 | HSD17B10 (0.40) | PDE2ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401270-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097395-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-09-02 | — | — | WO | disclosed |