Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401735 | 0.84 | LRRK2 (0.68) | LRRK2ROCK2ROCK1CDC42BPBJAK3 | |
| SCHEMBL15401425 | 0.82 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL20308905 | 0.82 | LRRK2 (0.65) | LRRK2ROCK2ROCK1CDC42BPBJAK3 | |
| SCHEMBL15401053 | 0.78 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL31123686 | 0.78 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16835988 | 0.78 | LRRK2 (0.53) | LRRK2ROCK2ROCK1CDC42BPBMAPK1 | |
| SCHEMBL15401548 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPBJAK3 | |
| SCHEMBL15401565 | 0.77 | LRRK2 (1.00) | LRRK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL13695778 | 0.77 | LRRK2 (0.55) | LRRK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL26174645 | 0.77 | ROCK2 (0.51) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3339294-B1 | QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER THEREOF AS AXL INHIBIOTOR | SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN) | 2021-04-14 | — | — | EP | disclosed |
| WO-2017028797-A1 | PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER | 暨南大学 | 2017-02-23 | — | — | WO | disclosed |