Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28346717 | 0.92 | TRPA1 (0.58) | TRPA1ABCG2KDREGFRMET | |
| SCHEMBL28343434 | 0.90 | TRPA1 (0.56) | TRPA1ABCG2KDREGFRMET | |
| SCHEMBL31554425 | 0.84 | TRPA1 (0.47) | TRPA1ABCG2KDRACHEBACE1 | |
| SCHEMBL29487188 | 0.84 | PDGFRA (0.59) | KDRMET | |
| SCHEMBL174159 | 0.84 | PDGFRA (0.59) | KDRMET | |
| SCHEMBL23142492 | 0.80 | KDR (0.67) | TRPA1KDREGFRMETLCK | |
| SCHEMBL30250745 | 0.80 | KDR (0.67) | TRPA1KDREGFRMETLCK | |
| SCHEMBL5824789 | 0.79 | TRPA1 (0.76) | TRPA1KDREGFRMETLCK | |
| SCHEMBL23749502 | 0.79 | KDR (0.59) | TRPA1KDREGFRRET | |
| SCHEMBL371602 | 0.79 | ABCG2 (0.71) | ABCG2KDREGFRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473434-B | Substituted quinolone derivative or pharmaceutically acceptable salt or stereoisomer thereof, and medicinal composition and application thereof | 上海海和药物研究开发股份有限公司 | 2021-11-23 | — | — | CN | disclosed |
| EP-3339294-B1 | QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER THEREOF AS AXL INHIBIOTOR | SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN) | 2021-04-14 | — | — | EP | disclosed |
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
| US-20180265496-A1 | SUBSTITUTED QUINOLONE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | JINAN UNIVERSITY (CN) | 2018-09-20 | — | — | US | disclosed |
| CN-108473434-A | Substituted quinolone analog derivative or its pharmaceutically acceptable salt or stereoisomer and its Pharmaceutical composition and application | 暨南大学 | 2018-08-31 | — | — | CN | disclosed |
| EP-3339294-A1 | PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER | Jinan University (CN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017028797-A1 | PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER | 暨南大学 | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265496-A1 | SUBSTITUTED QUINOLONE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | NRAS, AXL, ABL1 | TRPA1 4106/4885ABCG2 309/4885KDR 404/4885 |
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | NRAS, AXL, ABL1 | TRPA1 4106/4885ABCG2 309/4885KDR 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.