Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.76 |
| ▸ | HSD3B2 | P26439 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL959660 | 1.00 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19HSD3B2 | |
| SCHEMBL959659 | 1.00 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19HSD3B2 | |
| SCHEMBL959571 | 0.91 | HSD11B1 (0.73) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1847308 | 0.91 | HSD11B1 (0.73) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL959570 | 0.91 | HSD11B1 (0.73) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL955608 | 0.90 | HSD11B1 (0.86) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL955610 | 0.90 | HSD11B1 (0.86) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL955606 | 0.90 | HSD11B1 (0.86) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13625238 | 0.89 | HSD11B1 (0.74) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL590318 | 0.88 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323994-A1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| EP-2183229-A1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2010010150-A1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009017671-A1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |