Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 13/20 | 0.67 |
| ▸ | FOLR1 | P15328 | 9/20 | 0.67 |
| ▸ | FOLR2 | P14207 | 8/20 | 0.67 |
| ▸ | SLC46A1 | Q96NT5 | 7/20 | 0.67 |
| ▸ | SLC19A1 | P41440 | 3/20 | 0.65 |
| ▸ | DHFR | P00374 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18551757 | 0.85 | GART (0.65) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18552561 | 0.85 | FOLR1 (0.70) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18552563 | 0.82 | GART (0.70) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18158248 | 0.81 | GART (1.00) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18551646 | 0.80 | GART (0.83) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18552512 | 0.80 | GART (0.70) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18540804 | 0.79 | GART (1.00) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18551644 | 0.79 | GART (1.00) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL18552514 | 0.76 | GART (0.70) | GARTFOLR1FOLR2SLC46A1SLC19A1 | |
| SCHEMBL28718440 | 0.76 | DHFR (0.74) | GARTFOLR1FOLR2SLC46A1SLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
| US-10457688-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-10-29 | — | — | US | disclosed |
| US-9994586-B2 | Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TYMS, THPO | GART 53/4885FOLR1 54/4885FOLR2 83/4885 |
| US-10457688-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TPX2, TYMS | GART 56/4885FOLR1 147/4885FOLR2 142/4885 |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | CYP4F3, TYMS, DPYD | GART 11/4885FOLR1 60/4885FOLR2 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.