Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3030261 | 0.82 | CYP2D6 (0.52) | CHRM2CHRM1CYP2D6MC4ROPRD1 | |
| SCHEMBL6233324 | 0.81 | CYP2D6 (0.50) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| SCHEMBL20883792 | 0.81 | CHRM2 (0.59) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| SCHEMBL3950480 | 0.81 | CYP2D6 (0.73) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| SCHEMBL42790 | 0.81 | CYP2D6 (0.73) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| SCHEMBL28140496 | 0.81 | MEN1 (0.46) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| SCHEMBL3956861 | 0.81 | CYP2D6 (0.73) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| SCHEMBL4155278 | 0.80 | CHRM2 (0.48) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4811700 | 0.79 | CYP2D6 (0.70) | CHRM2CHRM1CYP2D6MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4813790 | 0.79 | CYP2D6 (0.70) | CHRM2CHRM1CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017034377-A1 | PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) | DONG-A ST CO., LTD. (KR) | 2017-03-02 | — | — | WO | claimed |
| US-20170057955-A1 | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) | DONG-A ST CO., LTD. (KR) | 2017-03-02 | — | — | US | claimed |
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | claimed |
| CN-108699064-B | Hexahydropyrazino-triazinone derivatives as kinase inhibitors | UCB生物制药私人有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-106459046-B | Pyrazolo pyridine derivatives as kinase inhibitor | UCB生物制药私人有限公司 | 2019-01-08 | — | — | CN | disclosed |
| CN-108699064-A | Hexahydropyrazine and triazone derivatives as kinase inhibitor | UCB生物制药私人有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-105008360-B | The Pyrazolopyrimidine derivative of therapeutic activity | UCB生物制药私人有限公司 | 2017-09-19 | — | — | CN | disclosed |
| CN-106559992-A | As the bicyclic heteroaromatic derivative for condensing of kinase inhibitor | UCB生物制药私人有限公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-106507674-A | Fused bicyclic heteroaromatic derivatives as kinase inhibitors | UCB生物制药私人有限公司 | 2017-03-15 | — | — | CN | disclosed |
| WO-2017034377-A1 | PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) | DONG-A ST CO., LTD. (KR) | 2017-03-02 | — | — | WO | disclosed |
| US-20170057955-A1 | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) | DONG-A ST CO., LTD. (KR) | 2017-03-02 | — | — | US | disclosed |
| WO-2009071888-A1 | PYRROLOTHIAZOLES AS PI3-KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071895-A1 | FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |
| EP-2035436-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001076-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-01-03 | — | — | WO | disclosed |
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-5795977-A | Water soluble adenosine kinase inhibitors | METABASIS THERAPEUTICS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0836613-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5726302-A | SUBSTITUTED 4-AMINO PYRROLO(2,3-D) PYRIMIDINE AND PYRAZOLO(3,4-D) PYRIMIDINE NUCLEOSIDE ANALOGS | GENSIA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1996040707-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057955-A1 | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) | KDM1B, KDM1A, KDM3B | CHRM2 3095/4885CHRM1 2669/4885CYP2D6 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.