Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20899319 | 0.85 | CYP2D6 (0.50) | CHRM2CHRM1CYP2D6MC4ROPRD1 | |
| SCHEMBL1855362 | 0.80 | CHRM2 (0.53) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| SCHEMBL3950480 | 0.79 | CYP2D6 (0.73) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| SCHEMBL3956861 | 0.79 | CYP2D6 (0.73) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| SCHEMBL42790 | 0.79 | CYP2D6 (0.73) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL4813790 | 0.78 | CYP2D6 (0.70) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL4811700 | 0.78 | CYP2D6 (0.70) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL4470172 | 0.78 | CYP2D6 (0.70) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL17272266 | 0.78 | CYP2D6 (0.70) | CHRM2CHRM1MEN1KMT2ACYP2D6 | |
| SCHEMBL11962936 | 0.73 | CYP2D6 (0.37) | CYP2D6MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |