Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DGKA | P23743 | 1/20 | 0.42 |
| ▸ | POLM | Q9NP87 | 1/20 | 0.42 |
| ▸ | POLK | Q9UBT6 | 1/20 | 0.42 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.42 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PAM | P19021 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857907 | 0.78 | DGKA (0.39) | KMT2ASMN1; SMN2DGKATSHRLMNA | |
| SCHEMBL1401706 | 0.76 | DGKA (0.37) | KMT2ASMN1; SMN2DGKATSHRLMNA | |
| SCHEMBL3249448 | 0.76 | DGKA (0.37) | KMT2ASMN1; SMN2DGKATSHRLMNA | |
| SCHEMBL28084879 | 0.76 | POLM (0.50) | KMT2ASMN1; SMN2DGKAPOLMPOLK | |
| SCHEMBL42670 | 0.75 | HSD17B3 (0.42) | KMT2ATSHRMEN1ALDH1A1TDP1 | |
| SCHEMBL8932157 | 0.73 | HSD17B3 (0.41) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8505393 | 0.72 | DGKA (0.48) | KMT2ASMN1; SMN2DGKAPOLMPOLK | |
| SCHEMBL8506394 | 0.72 | DGKA (0.48) | KMT2ASMN1; SMN2DGKAPOLMPOLK | |
| SCHEMBL27480100 | 0.71 | POLM (0.52) | KMT2ASMN1; SMN2DGKAPOLMPOLK | |
| SCHEMBL28145047 | 0.71 | POLM (0.52) | KMT2ASMN1; SMN2DGKAPOLMPOLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340979-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035438-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2017-03-02 | — | — | WO | disclosed |