DGKA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ritanserin (SCHEMBL49227)	1.00	3/20
SCHEMBL15078	0.69	2/20
SCHEMBL15079	0.69	2/20
SCHEMBL43555	0.69	2/20
SCHEMBL43557	0.69	2/20
SCHEMBL79292	0.69	2/20
SCHEMBL79293	0.69	2/20
SCHEMBL79772	0.69	2/20
SCHEMBL79773	0.69	2/20
SCHEMBL124225	0.69	2/20
SCHEMBL124226	0.69	2/20
SCHEMBL127134	0.69	2/20
SCHEMBL127136	0.69	2/20
SCHEMBL130324	0.69	2/20
SCHEMBL130326	0.69	2/20
Glyceryl Distearate (SCHEMBL118948)	0.69	2/20
SCHEMBL93861	0.65	2/20
SCHEMBL10411	0.64	2/20
SCHEMBL33706	0.64	2/20
SCHEMBL42627	0.64	2/20

Clinical trials — most relevant to DGKA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)	PHASE2	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Tissue Lipids and Insulin Resistance	nan	WITHDRAWN
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED
The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome	nan	UNKNOWN
Study of Changes in Skeletal Muscle After Caloric Restriction	nan	ACTIVE_NOT_RECRUITING
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
Effects of Obesity and Intensity of Exercise on Ghrelin Levels	nan	COMPLETED
Effects of Fish Oils on Inflammation and Insulin Resistance	nan	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity	nan	COMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
Extracellular Vesicles, Insulin Action, and Exercise	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a DGKA binder may also engage these)

Protein	Name	Similarity
P20192	—	1.000	P20192 →
DGKG	Diacylglycerol kinase gamma	1.000	landscape →
DGKB	Diacylglycerol kinase beta	1.000	landscape →
Q91WG7	—	1.000	Q91WG7 →
Q03603	—	1.000	Q03603 →
A0JN54	—	0.999	A0JN54 →
P51556	—	0.999	P51556 →
Q39017	—	0.999	Q39017 →
O88673	—	0.998	O88673 →
P49621	—	0.998	P49621 →
P49620	—	0.996	P49620 →
Q6C710	—	0.994	Q6C710 →
Q6NS52	—	0.993	Q6NS52 →
A0A131MCZ8	—	0.993	A0A131MCZ8 →
Q8IUF1	—	0.992	Q8IUF1 →
O44476	—	0.992	O44476 →
Q9TYU5	—	0.992	Q9TYU5 →
P27730	—	0.992	P27730 →
B4LX81	—	0.992	B4LX81 →
Q6CKE9	—	0.992	Q6CKE9 →
F2Y4A3	—	0.992	F2Y4A3 →
F4INY4	—	0.991	F4INY4 →
Q24592	—	0.991	Q24592 →
O14159	—	0.991	O14159 →
O94443	—	0.990	O94443 →
Q5JTY5	—	0.990	Q5JTY5 →
O76373	—	0.990	O76373 →
Q4R7L5	—	0.990	Q4R7L5 →
Q8L7L1	—	0.990	Q8L7L1 →
Q10028	—	0.990	Q10028 →