Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.55 |
| ▸ | ACE | P12821 | 9/20 | 0.55 |
| ▸ | MMEL1 | Q495T6 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18576535 | 1.00 | MME (0.55) | MMEACEMMEL1HPGD | |
| SCHEMBL18554148 | 1.00 | MME (0.55) | MMEACEMMEL1HPGD | |
| SCHEMBL18039451 | 0.88 | MEN1 (0.48) | MMEACEHPGD | |
| SCHEMBL18039612 | 0.88 | MEN1 (0.48) | MMEACEHPGD | |
| SCHEMBL18554351 | 0.83 | HPGD (0.45) | MMEACEHPGD | |
| SCHEMBL18554353 | 0.83 | HPGD (0.45) | MMEACEHPGD | |
| SCHEMBL18554141 | 0.83 | HPGD (0.45) | MMEACEHPGD | |
| SCHEMBL18554140 | 0.83 | HPGD (0.45) | MMEACEHPGD | |
| SCHEMBL18576534 | 0.83 | HPGD (0.45) | MMEACEHPGD | |
| SCHEMBL18576745 | 0.83 | HPGD (0.45) | MMEACEHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |