Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 6/20 | 0.40 |
| ▸ | ACE | P12821 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554351 | 1.00 | HPGD (0.45) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18576534 | 1.00 | HPGD (0.45) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18576745 | 1.00 | HPGD (0.45) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18554141 | 1.00 | HPGD (0.45) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18554140 | 1.00 | HPGD (0.45) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18576814 | 0.88 | GAA (0.44) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18576812 | 0.88 | GAA (0.44) | HPGDADRB1ADRB3ALOX5GPR88 | |
| SCHEMBL18576808 | 0.84 | HPGD (0.41) | HPGDALOX5GPR88MMEACE | |
| SCHEMBL18554145 | 0.83 | MME (0.55) | HPGDMMEACE | |
| SCHEMBL18576535 | 0.83 | MME (0.55) | HPGDMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |