Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554252 | 0.92 | ADORA2A (0.42) | TGFBR1TGFBR2SMN1; SMN2POLBADORA2A | |
| SCHEMBL18554321 | 0.91 | TGFBR1 (0.42) | TGFBR1TGFBR2SMN1; SMN2POLBADORA2A | |
| SCHEMBL18554274 | 0.86 | TGFBR1 (0.53) | TGFBR1TGFBR2SMN1; SMN2POLBHDAC1 | |
| SCHEMBL29363064 | 0.77 | POLB (0.39) | SMN1; SMN2POLBADORA2ANR3C1HDAC1 | |
| SCHEMBL22978895 | 0.77 | POLB (0.39) | SMN1; SMN2POLBADORA2ANR3C1HDAC1 | |
| SCHEMBL18554193 | 0.77 | TGFBR1 (0.55) | TGFBR1TGFBR2HDAC1HDAC3HDAC2 | |
| SCHEMBL18554233 | 0.76 | TGFBR1 (0.52) | TGFBR1TGFBR2ADORA2ACYP3A4HDAC1 | |
| SCHEMBL18583774 | 0.76 | TGFBR1 (0.56) | TGFBR1TGFBR2HDAC1HDAC3HDAC2 | |
| SCHEMBL22978902 | 0.75 | ADORA2A (0.46) | ADORA2ANR3C1HDAC1HDAC2HDAC6 | |
| SCHEMBL29365625 | 0.75 | ADORA2A (0.46) | ADORA2ANR3C1HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341372-A1 | TGF BETA RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035118-A1 | TGF BETA RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-02 | — | — | WO | disclosed |