Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 13/20 | 0.40 |
| ▸ | TACR1 | P25103 | 13/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15063077 | 0.92 | CNR1 (0.47) | CNR1CNR2TACR2TACR1HSD11B1 | |
| SCHEMBL1850677 | 0.90 | CNR1 (0.44) | CNR1CNR2TACR2TACR1HSD11B1 | |
| SCHEMBL1850887 | 0.87 | TACR2 (0.48) | CNR1CNR2TACR2TACR1RAB9A | |
| SCHEMBL2159375 | 0.85 | CNR1 (0.41) | CNR1CNR2TACR2TACR1ALDH1A1 | |
| SCHEMBL1846307 | 0.84 | CNR1 (0.40) | CNR1CNR2TACR2TACR1TACR3 | |
| SCHEMBL2159444 | 0.84 | CNR1 (0.38) | CNR1CNR2TACR2TACR1MEN1 | |
| SCHEMBL2159003 | 0.83 | CNR1 (0.39) | CNR1CNR2TACR2TACR1TACR3 | |
| SCHEMBL2159791 | 0.82 | CNR1 (0.49) | CNR1CNR2TACR2TACR1HSD11B1 | |
| SCHEMBL1850506 | 0.81 | CNR1 (0.49) | CNR1CNR2TACR2TACR1HSD11B1 | |
| SCHEMBL2159440 | 0.81 | CNR1 (0.41) | CNR1CNR2TACR2TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324015-B1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2013-07-03 | — | — | EP | disclosed |
| EP-2324015-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010012964-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-04 | — | — | WO | disclosed |