Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 7/20 | 0.71 |
| ▸ | IDH1 | O75874 | 16/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16392782 | 0.95 | IDH2 (0.77) | IDH2IDH1 | |
| SCHEMBL21573412 | 0.84 | IDH1 (0.67) | IDH2IDH1 | |
| SCHEMBL29560689 | 0.83 | IDH2 (0.66) | IDH2IDH1 | |
| SCHEMBL21573296 | 0.83 | IDH2 (1.00) | IDH2IDH1 | |
| SCHEMBL18186729 | 0.83 | IDH2 (0.66) | IDH2IDH1 | |
| SCHEMBL16392809 | 0.83 | IDH2 (1.00) | IDH2IDH1 | |
| SCHEMBL18557150 | 0.83 | IDH2 (0.76) | IDH2IDH1 | |
| SCHEMBL20938735 | 0.82 | IDH2 (0.76) | IDH2IDH1 | |
| SCHEMBL18557146 | 0.81 | IDH1 (0.54) | IDH2IDH1 | |
| SCHEMBL20402848 | 0.80 | IDH2 (0.67) | IDH2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579324-B2 | Therapeutically active compounds and their methods of use | AGIOS PHARMACEUTICALS, INC (US) | 2017-02-28 | — | — | US | disclosed |