Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.67 |
| ▸ | IDH2 | P48735 | 6/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16393283 | 0.91 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL16393075 | 0.91 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL21573335 | 0.89 | IDH1 (0.65) | IDH1IDH2 | |
| SCHEMBL17971618 | 0.88 | IDH1 (0.87) | IDH1IDH2 | |
| SCHEMBL18557108 | 0.88 | IDH1 (0.87) | IDH1IDH2 | |
| SCHEMBL21573547 | 0.86 | IDH1 (0.83) | IDH1IDH2 | |
| SCHEMBL29599204 | 0.86 | IDH1 (0.83) | IDH1IDH2 | |
| SCHEMBL21573377 | 0.86 | IDH1 (0.83) | IDH1IDH2 | |
| SCHEMBL18557071 | 0.84 | IDH2 (0.71) | IDH1IDH2 | |
| SCHEMBL21573329 | 0.83 | IDH1 (0.52) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019483-B1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-11-20 | — | — | EP | disclosed |