Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.49 |
| ▸ | MERTK | Q12866 | 2/20 | 0.49 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21573363 | 1.00 | GPR39 (0.56) | GPR39KDM4ENPSR1SMN1; SMN2TDP1 | |
| SCHEMBL20402919 | 1.00 | GPR39 (0.56) | GPR39KDM4ENPSR1SMN1; SMN2TDP1 | |
| SCHEMBL19240855 | 0.81 | PDE4A (0.55) | KDM4ESMN1; SMN2PDE4ARAB9AMAPT | |
| SCHEMBL15131535 | 0.78 | IDH1 (0.64) | PDE4ARAB9AIDH1IDH2 | |
| SCHEMBL17971630 | 0.76 | METAP1 (0.56) | GPR39KDM4ESMN1; SMN2TDP1LMNA | |
| SCHEMBL29763317 | 0.75 | TDP1 (0.51) | KDM4ESMN1; SMN2TDP1LMNAHTT | |
| SCHEMBL15102645 | 0.75 | TDP1 (0.51) | KDM4ESMN1; SMN2TDP1LMNAHTT | |
| SCHEMBL29763352 | 0.75 | MAPK14 (0.46) | GPR39TRPM8FLT3TYRO3MERTK | |
| SCHEMBL15102280 | 0.75 | MAPK14 (0.46) | GPR39TRPM8FLT3TYRO3MERTK | |
| SCHEMBL15094872 | 0.75 | GBA1 (0.54) | KDM4ENPSR1SMN1; SMN2LMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579324-B2 | Therapeutically active compounds and their methods of use | AGIOS PHARMACEUTICALS, INC (US) | 2017-02-28 | — | — | US | disclosed |