GPR39 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10086642	0.53	12/20
SCHEMBL3662536	0.55	9/20
SCHEMBL7546716	0.43	9/20
SCHEMBL797462	0.60	5/20
SCHEMBL415522	0.51	4/20
SCHEMBL416423	0.51	4/20
SCHEMBL12283769	0.46	4/20
SCHEMBL4903268	0.41	4/20
SCHEMBL604517	0.55	3/20
SCHEMBL3663909	0.54	3/20
SCHEMBL3662804	0.52	3/20
SCHEMBL1774715	0.50	3/20
SCHEMBL4720018	0.50	3/20
SCHEMBL1443136	0.46	3/20
SCHEMBL1775866	0.44	3/20
SCHEMBL7245120	0.43	3/20
SCHEMBL5476416	0.43	3/20
SCHEMBL1924850	0.43	3/20
SCHEMBL3511163	0.42	3/20
SCHEMBL9228056	0.42	3/20

Clinical trials — most relevant to GPR39 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Dose-response Study Examining the Contribution of GLP-1 Receptor Signaling to Glucagon-stimulated Insulin Secretion	PHASE3	COMPLETED
Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis	PHASE2/PHASE3	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Effect of GSK962040 on Oesophageal Function	PHASE1	COMPLETED
Intestinal Glucagon-like Peptide-1 (GLP-1) and the Physiological Role in Eating in Humans	PHASE1	COMPLETED
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	nan	COMPLETED
The Role of GLP-1 in Satiety Perception in Humans	nan	WITHDRAWN
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma	nan	UNKNOWN
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a GPR39 binder may also engage these)

Protein	Name	Similarity
B4XF06	—	1.000	B4XF06 →
Q5U431	—	1.000	Q5U431 →
B2ZHY2	—	0.998	B2ZHY2 →
NMUR2	Neuromedin-U receptor 2	0.983	landscape →
Q8BZ39	—	0.980	Q8BZ39 →
P20789	—	0.979	P20789 →
O88319	—	0.979	O88319 →
Q60613	—	0.978	Q60613 →
O55040	—	0.977	O55040 →
Q58CW4	—	0.977	Q58CW4 →
Q91178	—	0.977	Q91178 →
P11617	—	0.976	P11617 →
A0A2R9YJI3	—	0.975	A0A2R9YJI3 →
P50129	—	0.975	P50129 →
GPR139	Probable G-protein coupled receptor 139	0.974	landscape →
P56490	—	0.974	P56490 →
Q9ESQ4	—	0.974	Q9ESQ4 →
O46635	—	0.973	O46635 →
NTSR1	Neurotensin receptor type 1	0.973	landscape →
P46616	—	0.973	P46616 →
Q9JJI5	—	0.972	Q9JJI5 →
Q5R4Q6	—	0.972	Q5R4Q6 →
Q75Z89	—	0.972	Q75Z89 →
Q99680	—	0.972	Q99680 →
Q98895	—	0.972	Q98895 →
P30543	—	0.971	P30543 →
D4A3U0	—	0.971	D4A3U0 →
P70259	—	0.971	P70259 →
O54798	—	0.971	O54798 →
P47752	—	0.971	P47752 →